Articles

• Pinzi L*, Conze C*, Bisi N, Dalla Torre G, Soliman A, Monteiro-Abreu N, Trushina NI, Krusenbaum A, Khodaei Dolouei M, Hellwig A, Christodoulou MS, Passarella D, Bakota L, Rastelli G#, and Brandt R# (2024) Quantitative live cell imaging of a tauopathy model enables the identification of a polypharmacological drug candidate that restores physiological microtubule interaction. Nat. Commun. 15:1679 (*joint first authors) (#joint corresponding authors). bioRxiv link.


• Bakota L, and Brandt R (2024) Why kiss-and-hop explains that tau does not stabilize microtubules and does not interfere with axonal transport (at physiological conditions). Cytoskeleton 81:47-52


• Conze C, Trushina NI, and Brandt R (2023) Molekulare Medizin: Live cell imaging zeigt, wie Tau den axonalen Transport ausbremst. BIOspektrum 04.23:365-368


• Söhnel AC, and Brandt R (2023) Neuronal stress granules as dynamic microcompartments: Current concepts and open questions. Biol. Chem. 404:491-498


• Rierola M, Trushina NI, Holtmannspotter M, Kurre R, and Bakota L (2023) Lattice light-sheet microscopy and evaluation of dendritic transport in cultured hippocampal tissue reveal high variability in mobility of the KIF1A motor domain and entry into dendritic spines. Brain Res. Bull. 194:13-22


• Conze C*, Trushina NI*, Holtmannspotter M, Rierola M, Attanasio S, Bakota L, Piehler J, and Brandt R (2022) Super-resolution imaging and quantitative analysis of microtubule arrays in model neurons show that epothilone D increases the density but decreases the length and straightness of microtubules in axon-like processes. Brain Res. Bull. 190:234-243 (*joint first authors)


• Conze C, Rierola M, Trushina NI, Peters M, Janning D, Holzer M, Heinisch JJ, Arendt T, Bakota L and Brandt R (2022) Caspase-cleaved tau is senescence-associated and induces a toxic gain of function by putting a brake on axonal transport. Mol. Psychiatry 27:3010-3023


• Söhnel AC, Trushina NI, and Brandt R (2022) Monitoring and quantification of the dynamics of stress granule components in living cells by fluorescence decay after photoactivation. Methods Mol. Biol. 2428:243-259


• Soliman A, Bakota L, and Brandt R (2022) Microtubule-modulating agents in the fight against neurodegeneration: Will it ever work? Curr. Neuropharmacology 20:782-798.


• Brandt R, Trushina NI, and Bakota L (2020) Much more than a cytoskeletal protein: Physiological and pathological functions of the non-microtubule binding region of tau. Front. Neurol. 11:590059


• Niewidok B, Kurre R, and Brandt R (2020) Nanocores and Liquid Droplets: Single-molecule microscopy of neuronal stress granule components. In: Single Molecule Microsopy in Neurobiology. Springer: Neuromethods 154:39-57


• Hrynchak MV*, Rierola M*, Golovyashkina N, Penazzi L, Pump WC, David B, Sündermann F, Brandt, and Bakota L (2020) Chronic presence of oligomeric Aβ differentially modulates spine parameters in the hippocampus and cortex of mice with low APP transgene expression. Front. Synaptic Neurosci. 12:16 (*joint first authors), also part of the Frontiers e-book "The Synaptic Basis of Neuropathology"


• Ortiz-Sanz C, Valero J, Bakota L, Brandt R, Zugaza JL, Matute C, and Alberdi E (2020) Early effects of amyloid beta oligomers on dendritic spine dynamics and arborization in hippocampal neurons. Front. Synaptic Neurosci. 12:2


• Trushina NI, Bakota L, Mulkidjanian AY, and Brandt R (2019) The evolution of tau phosphorylation and interactions. Front. Aging Neurosci. 11:256


• Trushina NI, Mulkidjanian AY, and Brandt R (2019) The microtubule skeleton and the evolution of neuronal complexity in vertebrates. Biol. Chem. 400:1163-1179


• Schob C, Morellini F, Ohana O, Bakota L, Hrynchak MV, Brandt R, Brockmann MD, Cichon N, Hartung H, Hanganu-Opatz IL, Kraus V, Scharf S, Herrmans-Borgmeyer I, Schweizer M, Kuhl D, Wöhr M, Vörckel KJ, Calzada-Wack J, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Garner CC, Kreienkamp HJ, Kindler S (2019) Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice. Transl. Psychiatry 9:7


• Gauthier-Kemper A*, Suárez Alonso M*, Sündermann F, Niewidok B, Fernandez MP, Bakota L, Heinisch JJ, Brandt R (2018) Annexins A2 and A6 interact with the extreme N-terminus of tau and thereby contribute to tau’s axonal localization (*joint first authors). J. Biol. Chem. 293:8065-8076


• Niewidok B*, Igaev M*, Pereira da Graca A, Strassner A, Lenzen C, Richter CP, Piehler J, Kurre R and Brandt R (2018) Single-Molecule Imaging Reveals Dynamic Biphasic Partition of RNA-Binding Proteins in Stress Granules. (*joint first authors) J. Cell Biol. 217:1303–1318 (graphical abstract)


• Brandt R, and Bakota L (2017) Microtubule dynamics and the neurodegenerative triad of Alzheimer's disease: The hidden connection. J. Neurochem. 143:409-417 (2018 top downloaded paper)


• Bakota L, Ussif A, Jeserich G, and Brandt R (2017) Systemic and network functions of the microtubule-associated protein tau: Implications for tau-based therapies. Mol. Cell. Neuroscience 84:132-141


• Penazzi L, Lorengel J, Sündermann F, Golovyashkina N, Marre S, Mathis CMB, Lewejohann L, Brandt R, and Bakota L (2017) DMSO modulates CNS function in a preclinical Alzheimer's disease model. Neuropharmacology 113:434-444


• Niewidok B*, Igaev M*, Sündermann F, Janning D, Bakota L, and Brandt R (2016) Presence of a carboxyterminal pseudo-repeat and disease-like pseudohyperphosphorylation critically influence tau’s interaction with microtubules in axon-like processes. (*joint first authors) Mol. Biol. Cell 27:3537-3549 (Third MBoC special issue on quantitative biology)


• Heinisch JJ, and Brandt R (2016) Signaling pathways and posttranslational modifications of tau in Alzheimer's disease: how humanized can yeast cells become? Microb. Cell. 3:132-188


• Sündermann F, Fenandez MP, and Morgan RO (2016) An evolutionary roadmap to the microtubule-associated protein MAP Tau. BMC Genomics 17:264


• Penazzi L*, Tackenberg C*, Ghori A, Golovyashkina N, Niewidok B, Selle K, Ballatore C, Smith III AB, Bakota L, and Brandt R (2016) Abeta-mediated spine changes in the hippocampus are microtubule-dependent and can be reversed by a subnanomolar concentration of the microtubule-stabilizing agent epothilone D. (*joint first authors) Neuropharmacology 105:84-95


• Bongard D, Degefa TH, Schön P, Giese M, Brandt R, and Walder L (2016) Evaluation and elucidation of DNA-containing viologen-dendrimer complex formation. Eur. J. Org. Chem. 10:1897-1907


• Bakota L, and Brandt R (2016) Tau Biology and Tau-Directed Therapies for Alzheimer's Disease. Drugs 76:301-313


• Penazzi L, Bakota L, and Brandt R (2016) Microtubule dynamics in neuronal development, plasticity and neurodegeneration. Int. Rev. Cell Mol. Biol. 321:89-169 (cover illustration)


• Golovyashkina N, Penazzi L, Ballatore C, Smith III AB, Bakota L, and Brandt R (2015) Region-specific dendritic simplification induced by Abeta, mediated by tau via dysregulation of microtubule dynamics: a mechanistic distinct event from other neurodegenerative processes. Molecular Neurodegeneration 10:60


• Raasch K, Malecki E, Siemann M, Montilla Martinez M, Heinisch JJ, Müller J, Bakota L, Kaltschmidt C, Kaltschmidt B, Rosemeyer H, and Brandt R (2015) Identification of nucleoside analogues as inducers of neuronal differentiation in a human reporter cell line and adult stem cells. Chem. Biol. Drug Des. 86:129-143 (graphical abstract) (cover illustration)


• Igaev M, Janning D, Sündermann F, Niewidok B, Brandt R, and Junge W (2014) A refined reaction-diffusion model of tau-microtubule dynamics and its application in FDAP analysis. Biophys. J. 107:2567-2578


• Bongard D, Bohr W, Swierczek M, Degefa TH, Walder L, and Brandt R (2014) Alkylene-bridged viologen dendrimers: A versatile cell delivery tool with biosensing properties. Org. Biomol. Chem. 12:9583-91


• Janning D*, Igaev M*, Sündermann F, Brühmann J, Beutel O, Heinisch JJ, Bakota L, Piehler J, Junge W, and Brandt R (2014) Single molecule tracking of tau reveals fast kiss-and-hop interaction with microtubules in living neurons. (*joint first authors) Mol. Biol. Cell 25:3541-3551 (First MBoC special issue on quantitative biology) (featured at 'HighMag')


• Gauthier-Kemper A, Igaev M, Sündermann F, Janning D, Brühmann J, Moschner K, Reyher HJ, Junge W, Glebov K, Walter J, Bakota L, and Brandt R (2014) Interplay between phosphorylation and palmitoylation mediates plasma membrane targeting and sorting of GAP43. Mol. Biol. Cell 25:3285-3299


• Moschner K*, Sündermann F*, Meyer H, Pereira da Graca A, Appel N, Paululat A, Bakota L, and Brandt R (2014) RNA-protein granules modulate tau isoform expression and induce neuronal sprouting. (*joint first authors) J. Biol. Chem. 289:16814-16825


• Tackenberg C, Ghori A, and Brandt R (2014) Thin, stubby or mushroom: Spine pathology in Alzheimer's Disease. In: Advances in Alzheimer's Research Vol. 2, Bentham eBook, pp. 375-394


• Sündermann F, Lotter S, Lim WQ, Golovyashkina N, Brandt R, and Kutyniok G (2014) Shearlet-analysis of confocal laser-scanning microscopy images to extract morphological features of neurons. NeuroMethods 87:293-303


• Penazzi L, Sündermann F, Bakota L, and Brandt R (2014) Machine learning to evaluate neuron density in brain sections. NeuroMethods 87:263-291


• Golovyashkina N, Sündermann F, Brandt R, and Bakota L (2014) Reconstruction and morphometric analysis of hippocampal neurons from mice expressing fluorescent proteins. NeuroMethods 87:251-262


• Tackenberg C, Grinschgl S, Trutzel A, Santuccione AC, Frey MC, Konietzko U, Grimm J, Brandt R, and Nitsch RM (2013) NMDA receptor subunit composition determines beta amyloid-induced neurodegeneration and synaptic loss. Cell Death Dis. 4:e608


• Brandt R, and Paululat A (2013) Microcompartments in the Drosophila heart and the mammalian brain: General features and common principles. Biol. Chem. 394:217-230 (cover illustration)


• Fanara P, Wong PY, Husted KH, Liu S, Liu VM, Kohlstaedt LA, Riiff T, Protasio JC, Boban D, Killion S, Killian M, Epling L, Sinclair E, Peterson J, Price RW, Cabin DE, Nussbaum RL, Brühmann J, Brandt R, Christine CW, Aminoff MJ, and Hellerstein MK (2012) Preclinical and clinical cerebrospinal fluid kinetic biomarkers of axonal transport. J. Clin. Invest. 122:3159-3169 (commentary) (press release by KineMed Inc.)


• Tennstaedt A, Pöpsel S, Truebestein L, Hauske P, Brockmann A, Schmidt N, Irle I, Sacca B, Niemeyer CM, Brandt R, Ksiezak-Reding H, Tirniceriu AL, Egensperger R, Baldi A, Dehmelt L, Kaiser M, Huber R, Clausen T, and Ehrmann M (2012) Human high temperature requirement serine protease A1 (Htra1) degrades tau protein aggregates. J. Biol. Chem. 287:20931-20941


• Bakota L, Brandt R, and Heinisch JJ (2012) Triple mammalian/yeast/bacterial shuttle vectors for single and combined Lentivirus- and Sindbis virus-mediated infections of neurons. Mol. Genet. Genomics 287:313-324


• Sündermann F, Golovyashkina N, Tackenberg C, Brandt R, and Bakota L (2012) High-resolution imaging and evaluation of spines in organotypic hippocampal slice cultures. Methods Mol. Biol. 846:277-293


• Gauthier-Kemper A, Weissmann C, Reyher HJ, and Brandt R (2012) Monitoring cytoskeletal dynamics in living neurons using fluorescence photoactivation. Methods Enzymol. 505:3-21


• Hundelt M, Fath T, Selle K, Oesterwind K, Jordan J, Schultz C, Götz J, von Engelhardt J, Monyer H, Lewejohann L, Sachser N, Bakota L, and Brandt R (2011) Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation. Neurobiol Aging 32:991-1006


• Gauthier-Kemper A, Weissmann C, Golovyashkina N, Sebö-Lemke Z, Drewes G, Gerke V, Heinisch JJ, and Brandt R. (2011) The frontotemporal dementia mutation R406W blocks tau’s interaction with the membrane in an annexin A2-dependent manner. J. Cell Biol. 192:647-661 (featured in JCB: "Annexin keeps tau on a short leash")


• Balderhaar HJ, Arlt H, Ostrowicz C, Bröcker C, Sündermann F, Brandt R, Babst M, Ungermann C (2010) The Rap-GTPase Ypt7 is linked to retromer-mediated receptor recycling and fusion at the yeast late endosome. J. Cell Sci. 123:4085-4094


• Gauthier A, and Brandt R (2010) Live cell imaging of cytoskeletal dynamics in neurons using fluorescence photoactivation. Biol. Chem 391:639-643 (cover illustration)


• Fanara P, Husted KH, Selle K, Wong PY, Banerjee J, Brandt R, Hellerstein MK (2010) Changes in microtubule turnover accompany synaptic plasticity and memory formation in response to contextual fear-conditioning in mice. Neuroscience 168:167-178 (press release by KineMed Inc.)


• Rosenzweig S, Raz-Prag D, Nitzan A, Galron R, Paz M, Jeserich G, Neufeld G, Barzilai A, and Solomon AS (2010) Sema-3A indirectly disrupts the regeneration process of goldfish optic nerve after controlled injury. Graefes Arch Clin Exp Ophthalmol. 248:1423-35


• Tackenberg C, and Brandt R (2009) Divergent pathways mediate spine alterations and cell death induced by amyloid-b, wild-type tau, and R406W tau. J. Neurosci. 29:14439-14450 (featured in "This week in the journal") (recommended paper by the "Faculty of 1000") (featured by the "Alzheimer research forum")


• Weissmann C, Reyher HJ, Gauthier A, Steinhoff HJ, Junge W, and Brandt R (2009) Microtubule binding and trapping at the tip of neurites regulate tau motion in living neurons. Traffic 10:1655-1668


• Bakota L, and Brandt R (2009) Live cell imaging in the study of neurodegeneration. Int. Rev. Cell Mol. Biol. 276:49-103


• Tackenberg C, Ghori A, and Brandt R (2009) Thin, stubby or mushroom: Spine pathology in Alzheimer's disease. Curr. Alzheimer Res. 6:261-268


• Brandt R, Gergou A, Wacker I, Fath T, and Hutter H (2009) A Caenorhabditis elegans model of tau hyperphosphorylation: Induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau. Neurobiol. Aging 30:22-33


• Weissmann C, and Brandt R (2008) Mechanisms of neurodegenerative diseases: Insights from live cell imaging. J. Neurosci. Res. 86:504-511


• Hundelt M, and Brandt R (2008) Tauopathy in Alzheimer's disease. In: Research progress in Alzheimer's disease and dementia (ed. M.K. Sun), Vol. 3, Nova Science Publishers.(books.google)


• Deng Y, Li B, Liu F, Iqbal K, Grundke-Iqbal I, Brandt R, and Gong CX (2008) Regulation between O-GlcNAcylation and phosphorylation of neurofilament-M and their dysregulation in Alzheimer disease. FASEB J. 22:138-145


• Klopfleisch S, Merkler D, Schmitz M, Klöppner S, Schedensack M, Jeserich G, Althaus HH, and Brück W (2008) Negative impact of statins on oligodendrocytes and myelin formation in vitro and in vivo. J Neurosci. 28:13609-14


• Jeserich G, Klempahn K, and Pfeiffer M (2008) Features and functions of oligodendrocytes and myelin proteins of lower vertebrate species. J Mol Neurosci. 35:117-26


• Fanara P, Banerjee J, Hueck RV, Harper MR, Awada M, Turner H, Husted KH, Brandt R, Hellerstein MK (2007) Stabilization of hyperdynamic microtubules is neuroprotective in ALS. J. Biol. Chem. 282:23465-23472 (cover illustration)


• Leschik J, Welzel A, Weissmann C, Eckert A, and Brandt R (2007) Inverse and distinct modulation of tau-dependent neurodegeneration by presenilin 1 and amyloid-beta in cultured cortical neurons. J. Neurochem. 101:1303-1315


• Shahani N, Subramaniam S, Wolf T, Tackenberg C, and Brandt R (2006) Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices. J. Neurosci. 26:6103-6114 (featured in "This week in the journal") (recommended paper by the "Alzheimer Research Forum")


• Lüdemann N, Clement A, Hans V, Leschik J, Behl C, and Brandt R (2005) O-Glycosylation of the tail domain of neurofilament protein M in human neurons and in spinal cord tissue of a rat model of amyotrophic lateral sclerosis (ALS). J. Biol. Chem. 280:31648-31658 (featured by "The ALS Association")


• Brandt R, Hundelt M, and Shahani N (2005) Tau alteration and neuronal degeneration in tauopathies: mechanisms and models. Biochem. Biophys. Acta 1739:331-354 (ScienceDirect TOP25 hottest article)


• Subramaniam S, Shahani N, Strelau J, Laliberté C, Brandt R, Kaplan D, and Unsicker K (2005) IGF-1 inhibits ERK to promote neuronal survival via the phosphatidylinositol-3 kinase/protein kinase-A/c-Raf pathway. J. Neurosci. 25:2838-2852


• Brandt R, and Leschik J (2004) Functional interactions of tau and their relevance for Alzheimer's disease. Curr. Alzheimer Res. 1:255-269


• Piwowarski T, Panofen F, and Jeserich G (2004) Molecular cloning and partial functional characterization of Tsha3--a novel modulatory potassium channel alpha-subunit of trout CNS. Brain Res Mol Brain Res. 124:124-33


• Morris JK, Willard BB, Yin X, Jeserich G, Kinter M, and Trapp BD (2004) The 36K protein of zebrafish CNS myelin is a short-chain dehydrogenase. Glia 45:378-91


• Henne J, and Jeserich G (2004) Maturation of spiking activity in trout retinal ganglion cells coincides with upregulation of Kv3.1- and BK-related potassium channels. J Neurosci Res. 75:44-54


• Piontek J, and Brandt R (2003) Differential and regulated binding of cAMP-dependent protein kinase and protein kinase C isoenzymes to gravin in human model neurons. J. Biol. Chem. 278:38970-38979


• Shahani N, and Brandt R (2002) Functions and malfunctions of the tau proteins. Cell. Mol. Life Sci. 59:1668-1680


• Fath T, Eidenmüller J, and Brandt R (2002) Tau-mediated cytotoxicity in a pseudohyperphosphorylation model of Alzheimer's disease. J. Neurosci. 22:9733-9741

Books and Special Issues

• Brandt R, and Götz J (Guest Editors) Special Issue on "Cytoskeletal Proteins in Health and Neurodegenerative Diseases" in: "Brain Research Bulletin", 2016 (Editorial).

• Bakota L, and Brandt R (Editors) Confocal and multiphoton laser-scanning microscopy of neuronal tissue: Applications and quantitative image analysis. New York: Humana Press, 2014 (Book info).

• Brandt R, Klare J, Steinhoff HJ, Ungermann C (Guest Editors) Highlight: "The physiology and dynamics of cellular microcompartments" in "Biol. Chem.", 2013 (Editorial).